Orbit Discovery - Delivering Peptide Discovery Solutions

Peptide Discovery

Delivering Peptide Discovery Solutions

What We Do

Orbit Discovery provides peptide discovery services for therapeutic applications, including radionuclide targeting, nucleic acid targeting, targeted protein degradation, soluble protein targeting and GPCR agonism and antagonism.

We combine our bead-based display system and microfluidics to perform high-throughput screening across very large chemical spaces.

Our services are customizable for both affinity screening (targeting binders) and direct functional screening (especially for agonism and antagonism) using proprietary reporter cell lines.

Our mission is to help partners identify peptide therapeutic hits through advanced high-throughput affinity and functional screening techniques.

The Orbit Display Bead:
Peptide and Encoding DNA: Linked

Applications

Radiopharmaceutical Targeting

Orbit Discovery finds peptide conjugates for precise radionuclide delivery. Using bead-based technology and flow cytometry, we identify high-affinity peptides for tumor-specific targets. Our diverse peptide libraries enhance target specificity while minimising off-target effects.

Functional Screening

Orbit's screening platform leverages microfluidics to screen directly for function against reporter cells, making it ideal for identifying GPCR agonists and antagonists. Our approach enables screens that are cover larger chemical space than traditional plate-based techniques.

Nucleic Acid Delivery

Orbit Discovery enhances peptide conjugate discovery for targeted RNA delivery. Using our bead-based technology, we identify peptides with strong affinities for disease-specific targets. As part of the validation process, we can screen large numbers of peptides for internalisation, ensuring accurate delivery for effective targeted therapies.

Soluble Protein Targeting

Orbit excels in discovering peptides against soluble proteins such as actuators for Target Protein Degradation. Our flexible platform supports multiple selections, counter-target screening, and precise tuning to binding sites, making it ideal for coupling high-affinity binders to ubiquitin ligases for PROTACs.

Our Platform

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Latest Updates

Orbit Discovery to Attend the 2024 European Association for Nuclear Medicine Congress

October 16, 2024

Orbit CEO, Neil Butt will be attending the 2024 European Association for Nuclear Medicine Congress in Hamburg, Germany from October 19th to 23rd. Come learn more about how Orbit is helping leading radiopharmaceutical companies discover novel peptide conjugates for radionuclide delivery.

Orbit Discovery to attend the 2024 European Peptide Symposium

July 15, 2024

Simon Bushell, will be attending the 37th European Peptide Symposium, to be held in August in Florence, Italy. This year the event is merged with the 14th International Peptide Symposium, and promises to be the biggest peptide event of the year.

Orbit Discovery to attend the 2024 Boulder Peptide Symposium

July 12, 2024

The Boulder Peptide Symposium continues to be the premier peptide discovery and development meeting of the year. Orbit Discovery will again be attending this year's event in September.