What we do
Orbit Discovery offer services for the discovery of peptides and other small biologic based moieties. Our services address high throughput screening of chemical space and allow for affinity screening and functional screening using both bead based technologies and microfuidics.
These technologies have been used to identify peptides as the starting point for peptidomimetic and small molecule therapeutics ,as well as bioconjugates for cell targeting and cargo delivery. Furthermore, the functional screening capabilities has allowed us to build screening cascades for the direct identification of functional peptides, in particular against GPCR’s.
Orbits mission is to offer our Partners solutions to identify therapeutic candidates by adopting high throughput affinity and functional screening.
Affinity Screening Service
A bead based peptide display engine, using FACS, allows for faster peptide discovery by binding affinity.
Functional Screening Service
The ability to display high peptide copy number allows discovery of functional peptides, such as agonists and antagonists, in primary screens
Target Production Services
The Orbit platform is target agnostic giving access to cell surface receptors, notably GPCRs and ion channels. We have a dedicated team focused on production of targets to ensure quality of starting materials
Single Cell Reporter Assay Services
Using expertise in cell line development and assay development, in conjunction with FACS, high content imaging and microfluidics, the Orbit platform can distinguish a functional response from single cells
Establishing a new standard
Orbit works with both industry and academic Partners to identify hits for existing and novel drug targets where therapeutic peptides can establish a new standard of care.