Current screening strategies can be categorised as either affinity strategies, where library molecules are scanned against the target molecule in isolation to find potential binders, or functional strategies, where ligands are tested against cells to see if they elicit a functional response. While affinity screening can produce large numbers of potential binders, the process of confirming functional modulation and binding specificity can be time consuming. Functional screening, while mitigating these concerns, is traditionally lower throughput. The Orbit Peptide Display Platform is a bead-based technology that overcomes these challenges by being a universal high-throughput screening platform capable of being used in both affinity and functional screening contexts. We have applied the platform to the identification of peptide agonists against GPCRs and other cell surface targets. Projects can utilise the full or partial suite  of Orbits capabilities, namely:

1. Complex membrane protein material preparation in a format representing functional conformation to ensure any binding peptides have relevance in functional assay
2. Reporter cell line development to assess functional activation of a target or the target functional pathways
3. Affinity screening to identify enriched library of peptide hits to functionally active target protein
4. Functional screening of enriched library to observe biologically functional hits suitable for future optimisation