Careers
The framework of Orbit is built on the strength of our team
Support and opportunity with Orbit
Orbit offers a competitive package and benefits associated with a fast moving start-up company. We have an open and collaborative culture and pride ourselves on the inclusive philosophy within the organization.
Current Opportunities
2 months ago
Research Scientist I/II – Chemistry
Overview of the Role
We are seeking a self-motivated, enthusiastic, and diligent Research Scientist to join our Chemistry team. You will play a key role in supporting the in-house production of peptides and the development of new capabilities within our chemistry laboratory. You will produce synthetic peptides (linear, cyclic, modified, bioconjugated to a range of biomolecules) in relation to internal and external projects. You will also support Orbit’s unique peptide display platform and help to broaden its capabilities by developing new building blocks and ligation techniques. The position is a lab-based role, demanding a proactive mindset, along with good time-management and organisational skills, an ability for problem solving, flexibility and attention to detail. The successful candidate will be given opportunities for training and development and will be encouraged to contribute to implementing new technologies and processes.Job Responsibilities
- Synthesize and modify peptides in solution and solid phase. Synthesize protected amino acid derivatives, various small molecules, and custom resin modification.
- Perform peptide modifications including biotinylation, fluorophore probes, and others.
- Perform and optimise peptide cyclisation.
- Perform peptide analysis by LC-MS and peptide purification using preparative HPLC and flash chromatography.
- Ensure that tasks are completed professionally and safely.
- Identify and develop novel techniques/capabilities to support the platform.
- Analyse, interpret and summarise results for presentation at internal meetings.
- Document research findings clearly in an electronic lab book.
- Produce project plans, reports, and SOPs.
- Contribute to general lab duties.
Job Requirements
Essential
- Prior laboratory research experience with synthesis and purification of peptides and small molecules.
- Expertise with biocompatible conjugation chemistry such as NCL and Click chemistry.
- Capacity to execute tasks independently to achieve company goals on an established timeline.
- Knowledge of, and appreciation for, laboratory safety procedures.
- Willingness to learn new techniques.
- Strong communication and team working skills.
- Capable of independently troubleshooting technical issues and ability to develop a solid understanding of the direction and design of a given project.
Desirable
- Experience with DNA—drug conjugation chemistry.
- Experience with peptide display technologies.
- Proficiency in software such as SciFinder, PyMol and ChemDraw.
3 months ago
Screening Scientist I – Affinity Screening
Overview of the Role
We are seeking three self-motivated, energetic, and diligent Scientist (level 1) to join our affinity screening team. Working within the Affinity Screening team, you will play a key role in designing and conducting affinity screens for a range of commercial and internal projects using Orbit Discovery’s unique bead-based peptide display engine to identify hit peptides for drug discovery. Work will involve the use of many techniques such as PCR, qPCR, in vitro transcription and translation, flow cytometry including sorting, microfluidics and next generation sequencing. You will also prepare data for reports and presentations within the company and assist in the drafting and review of laboratory protocols. Training will be provided for all techniques but expertise in flow cytometry, molecular biology or phage display are essential. The position is a lab-based role, demanding an enthusiastic and proactive mindset, along with good organisational skill, an ability for problem solving, flexibility and attention to detail. The successful candidate will be given opportunities for training and development and will be encouraged to contribute to implementing new technologies and processes.Job Responsibilities
- Independently design, perform and analyse experiments.
- Handling and preparation of beads for analysis by flow cytometry.
- Performing binding and sorting (FACS) experiments.
- Preparing, running, analysing and interpreting next generation sequencing.
- Performing PCR, in vitro transcription translation and other assays as required.
- Analyse, interpret and summarise results for presentation at internal meetings.
- Contributing to discussions and sharing research findings with colleagues.
- Documenting research findings clearly in an electronic lab book.
- Assist in producing and collating procedures, guidelines and reports.
- Prepare project plans and reports.
- Contribute to general lab duties.
- Ability to work flexibly and collaboratively to meet changing demands of projects.
Job Requirements
Essential
- A minimum of an MSc in a biology related discipline with two years of industry laboratory experience, or BSc and four years industry laboratory experience.
- Broad knowledge of biological sciences with an emphasis on molecular biology or protein binding.
- Expertise in flow cytometry or Phage display (including data analysis).
- Ability to design and perform experiments using molecular biology techniques such as PCR or qPCR.
- Ability to perform basic analytical techniques such as SDS-PAGE, Western blot or ELISA.
- Practical experience of assay development.
- Willingness to learn new techniques.
- Strong communication and team working skills.
- Capable of troubleshooting technical issues and ability to develop a solid understanding of the direction and design of a given project.
- Ability to independently follow a project plan as well as design and perform experiments within its remit and plan according to schedule of project plan.
Desirable
- Practical experience with other display technologies or screening platforms.
- Practical experience of assay development.
- Experience with next generation sequencing and bioinformatics.
- Practical experience in protein-protein interaction studies.
- Practical experience in FACS.
Work with us
Orbit is always interested in scientists with experience in molecular biology, assay development, protein expression. If you feel that you have the necessary qualities, we would like to hear from you.
