Engineering soluble and membrane bound proteins
Our flexible peptide display platforms allow for screening directly against both cells and recombinant target protein. The Orbit team incudes experts on structural biology and protein production to ensure the quality of target protein for affinity screening. Orbit has specific capabilities in the production and screening of traditionally challenging integral membrane proteins, including GPCRs and ion channels.
Membrane proteins can be screened either solubilised in detergent, or in reconstituted membrane systems such as nanodiscs or SMALPs to maintain a functional state after purification. In addition, Orbit develops target specific screening assays to facilitate the identification of functional therapeutic peptides during the screening processes.
Key Capabilities in Protein Engineering
GPCR engineering and production
Soluble protein engineering